Murine Survival Of Lethal Irradiation With Use Of Human Umbilical Cord Blood

Murine Survival Of Lethal Irradiation With Use Of Human Umbilical Cord Blood

Norman Ende, Nicholas M. Ponzio, Raghbir S. Athwal, Milton Ende, Dennis C. Giuliani

UMDNJ-New Jersey Medical School
Departments of Laboratory Medicine & Pathology; Microbiology and Molecular Genetics; Medicine – Hematology Division; Southside Regional Medical Center, Petersburg, VA

Summary

We have found that human umbilical cord blood (HUCB) will routinely protect mice exposed to lethal levels of irradiation. At the end of 50 days, over 70% of mice injected with HUBC survived 900 cGy of irradiation, which produced 100% deaths in the uninjected control animals.

Moreover, there was some evidence that human colony stimulating factors further improved survival. Anti-Natural Killer cell (NK) antibody was utilized along with HUCB in these studies, however, Anti-NK cell serum alone had no radioprotective effect in mice. The studies reported here suggest the possibility of utilizing HUCB for immediate protection of humans from lethal irradiation.

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