The Berashis Cell – A Review – Is It Similar To The Embryonic Stem Cell?

The Berashis Cell: A Review
Is It Similar To The Embryonic Cell

Norman Ende

Department of Pathology and Laboratory Medicine
New Jersey Medical School
185 South Orange Avenue, MSB-C501
Newark, NJ 07103

(Printed in Journal Of Medicine, Volumes 3 and 4, 2000)

Key Words: Berashis cells, embryonic stem cell, human cord blood
Abbreviations: HLA = Human lymphocyte antigen, SLE = systemic lupus erythematosis

Introduction

This article is an attempt to define very primitive pleuripotential and probably totipotential primitive cells found in umbilical cord blood and their clinical significance.

For lack of a better name, and in an effort to separate it from other “stem” cells, we have called it the “Berashis Cell” meaning “in the beginning” (בראשית) (Ende, 1995). Currently, we believe this cell exists in limited numbers in human umbilical cord blood, has never impacted on stroma, probably has some functional capacity at 4 degrees Celsius, and has few if any recognition antigens.

In its functional capacity it may be similar to that predicted for the embryonic stem cell derived from a fetus or embryos (Gerhart, 1998)

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