March 1990

Production Of Human To Mouse Xenografts By Umbilical Cord Blood

Utilizing human umbilical cord blood, it has been possible to create in irradiated animals a human to mouse xenograft. To facilitate hematopoietic reconstitution, SJL/J mice, which are functionally low in natural killer (NK) cells, were treated with anti-Asialo GM antibodies (anti-NK) and irradiation prior to injection of cord blood mononuclear cells.

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