Effect of Human Umbilical Cord Blood Mononuclear Cells On Preclinical Prostate Cancer Mice “Tramp”
Prostate cancer is almost exclusively a malignancy of men, particularly older men. There is significant evidence that the human immune system deteriorates with age. This deterioration may have a significant role in the development of cancer in the prostate. A mouse model “Tramp” is a preclinical model that spontaneously develops cancer that can metastasize and typically survives 252 to 280 days. This experiment involved two groups of “Tramp” mice. One group received human umbilical cord blood mononuclear cells, and the other group was the control. The average lifespan of the treatment group was 372 days, compared to 254 days for the control group.
Results from this study suggest practical benefits of stem cells for men who are prone to prostate cancer.
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